Research output per year
Research output per year
- 42 results
Search results
-
2022
Clinical Impact of Immune Checkpoint Inhibitor (ICI) Response, DNA Damage Repair (DDR) Gene Mutations and Immune-Cell Infiltration in Metastatic Melanoma Subtypes
Andrieu, C., McNamee, N., Larkin, A. M., Maguire, A., Menon, R., Mueller-Eisert, J., Horgan, N., Kennedy, S., Gullo, G., Crown, J. & Walsh, N., 24 May 2022, In: Medical sciences (Basel, Switzerland). 10, 2Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
2021
Generation and characterisation of a semi-synthetic siderophore-immunogen conjugate and a derivative recombinant triacetylfusarinine C–specific monoclonal antibody with fungal diagnostic application
Moloney, N. M., Larkin, A., Xu, L., Fitzpatrick, D. A., Crean, H. L., Walshe, K., Haas, H., Decristoforo, C. & Doyle, S., 1 Nov 2021, In: Analytical Biochemistry. 632, 114384.Research output: Contribution to journal › Article › peer-review
Open Access4 Citations (Scopus) -
2020
Genomic Profiling and Functional Analysis of let-7c miRNA-mRNA Interactions Identify SOX13 to Be Involved in Invasion and Progression of Pancreatic Cancer
Nelson, S. R., Roche, S., Cotter, M., Garcia, P. A., Reitmeier, D., Zollbrecht, E., O'Neill, F., Clynes, M., Doolan, P., Medha, J. P., Swan, N., Larkin, A. M. & Walsh, N., 2020, In: Journal of Oncology. 2020, 2951921.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Modelling of pancreatic cancer biology: transcriptomic signature for 3D PDX-derived organoids and primary cell line organoid development
Nelson, S. R., Zhang, C., Roche, S., O’Neill, F., Swan, N., Luo, Y., Larkin, A. M., Crown, J. & Walsh, N., 1 Dec 2020, In: Scientific Reports. 10, 1, 2778.Research output: Contribution to journal › Article › peer-review
Open Access31 Citations (Scopus) -
PRDX3 is associated with metastasis and poor survival in uveal melanoma
Ramasamy, P., Ramasamy, P., Ramasamy, P., Larkin, A. M., Larkin, A. M., Linge, A., Tiernan, D., McAree, F., Horgan, N., Moriarty, P., Beatty, S., Murphy, C. C., Murphy, C. C., Clynes, M., Clynes, M., Kennedy, S. & Meleady, P., 1 Jul 2020, In: Journal of Clinical Pathology. 73, 7, p. 408-412 5 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2019
Current and future biomarkers for risk-stratification and treatment personalisation in multiple myeloma
Le, G. N., Bones, J., Coyne, M., Bazou, D., Dowling, P., O'Gorman, P. & Larkin, A. M., 2019, In: Molecular Omics. 15, 1, p. 7-20 14 p.Research output: Contribution to journal › Review article › peer-review
11 Citations (Scopus) -
2018
An insight into the molecular genetics of a uveal melanoma patient cohort
Kennedy, S., Rice, M., Toomey, S., Horgan, N., Hennessey, B. T. & Larkin, A., 1 Oct 2018, In: Journal of Cancer Research and Clinical Oncology. 144, 10, p. 1861-1868 8 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2017
A novel inhibitory anti-invasive MAb isolated using phenotypic screening highlights AnxA6 as a functionally relevant target protein in pancreatic cancer
O'Sullivan, D., Dowling, P., Joyce, H., Mcauley, E., Mccann, A., Henry, M., Mcgovern, B., Barham, P., Kelleher, F. C., Murphy, J., Kennedy, S., Swan, N., Moriarty, M., Clynes, M. & Larkin, A., 2017, In: British Journal of Cancer. 117, 9, p. 1326-1335 10 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Novel panel of protein biomarkers to predict response to bortezomib-containing induction regimens in multiple myeloma patients
Ting, K. R., Henry, M., Meiller, J., Larkin, A., Clynes, M., Meleady, P., Bazou, D., Dowling, P. & O'Gorman, P., Dec 2017, In: BBA Clinical. 8, p. 28-34 7 p.Research output: Contribution to journal › Article › peer-review
Open Access16 Citations (Scopus) -
Polyclonal Immunoglobulin G N-Glycosylation in the Pathogenesis of Plasma Cell Disorders
Mittermayr, S., Lê, G. N., Clarke, C., Millán Martín, S., Larkin, A. M., O'Gorman, P. & Bones, J., 3 Feb 2017, In: Journal of Proteome Research. 16, 2, p. 748-762 15 p.Research output: Contribution to journal › Article › peer-review
32 Citations (Scopus) -
2016
Quantitative label-free mass spectrometry analysis of formalin-fixed, paraffin-embedded tissue representing the invasive cutaneous malignant melanoma proteome
Dowling, P., Moran, B., McAuley, E., Meleady, P., Henry, M., Clynes, M., McMenamin, M., Leonard, N., Monks, M., Wynne, B., Ormond, P. & Larkin, A., Nov 2016, In: Oncology Letters. 12, 5, p. 3296-3304 9 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
2015
Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer
Dowling, P., Pollard, D., Larkin, A., Henry, M., Meleady, P., Gately, K., O'Byrne, K., Barr, M. P., Lynch, V., Ballot, J., Crown, J., Moriarty, M., O'Brien, E., Morgan, R. & Clynes, M., 1 Mar 2015, In: Molecular BioSystems. 11, 3, p. 743-752 10 p.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
Elevated levels of 14-3-3 proteins, serotonin, gamma enolase and pyruvate kinase identified in clinical samples from patients diagnosed with colorectal cancer
Dowling, P., Hughes, D. J., Larkin, A. M., Meiller, J., Henry, M., Meleady, P., Lynch, V., Pardini, B., Naccarati, A., Levy, M., Vodicka, P., Neary, P. & Clynes, M., 4 Feb 2015, In: Clinica Chimica Acta. 441, p. 133-141 9 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Influence of multidrug resistance and drug transport proteins on chemotherapy drug metabolism
Joyce, H., McCann, A., Clynes, M. & Larkin, A., 1 May 2015, In: Expert Opinion on Drug Metabolism and Toxicology. 11, 5, p. 795-809 15 p.Research output: Contribution to journal › Review article › peer-review
66 Citations (Scopus) -
2014
7B7: A novel antibody directed against the Ku70/Ku80 heterodimer blocks invasion in pancreatic and lung cancer cells
O'Sullivan, D., Henry, M., Joyce, H., Walsh, N., Auley, E. M., Dowling, P., Swan, N., Moriarty, M., Barnham, P., Clynes, M. & Larkin, A., Jun 2014, In: Tumor Biology. 35, 7, p. 6983-6997 15 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Erratum to: Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours (Breast Cancer Res Treat, (2012), 136, (717-727), 10.1007/s10549-012-2260-9)
Browne, B. C., Eustace, A. J., Kennedy, S., O’Brien, N. A., Pedersen, K., McDermott, M. S. J., Larkin, A., Ballot, J., Mahgoub, T., Sclafani, F., Madden, S., Kennedy, J., Duffy, M. J., Crown, J. & O’Donovan, N., 25 Nov 2014, In: Breast Cancer Research and Treatment. 148, 3, p. 697 1 p.Research output: Contribution to journal › Comment/debate
Open Access -
Evaluation of chromogenic in situ hybridization for the determination of monosomy 3 in uveal melanoma
Gleeson, G., Larkin, A., Horgan, N. & Kennedy, S., May 2014, In: Archives of Pathology and Laboratory Medicine. 138, 5, p. 664-670 7 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
Identification and functional validation of rad23b as a potential protein in human breast cancer progression
Linge, A., Maurya, P., Friedrich, K., Baretton, G. B., Kelly, S., Henry, M., Clynes, M., Larkin, A. & Meleady, P., 3 Jul 2014, In: Journal of Proteome Research. 13, 7, p. 3212-3222 11 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
Predictive biomarkers for dasatinib treatment in melanoma
Eustace, A. J., Kennedy, S., Larkin, A. M., Mahgoub, T., Tryfonopoulos, D., O'Driscoll, L., Clynes, M., Crown, J. & O'Donovan, N., 2014, In: Oncoscience. 1, 2, p. 158-166 9 p.Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
2013
EGFR and HER2 inhibition in pancreatic cancer
Walsh, N., Kennedy, S., Larkin, A., Corkery, B., O'Driscoll, L., Clynes, M., Crown, J. & O'Donovan, N., Jun 2013, In: Investigational New Drugs. 31, 3, p. 558-566 9 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
2012
Differential expression of fourteen proteins between uveal melanoma from patients who subsequently developed distant metastases versus those who did not
Linge, A., Kennedy, S., O'Flynn, D., Beatty, S., Moriarty, P., Henry, M., Clynes, M., Larkin, A. & Meleady, P., Jul 2012, In: Investigative Ophthalmology and Visual Science. 53, 8, p. 4634-4643 10 p.Research output: Contribution to journal › Article › peer-review
58 Citations (Scopus) -
Evaluation of IGF1R and phosphorylated IGF1R as targets in HER2-positive breast cancer cell lines and tumours
Browne, B. C., Eustace, A. J., Kennedy, S., O'Brien, N. A., Pedersen, K., McDermott, M. S. J., Larkin, A., Ballot, J., Mahgoub, T., Sclafani, F., Madden, S., Kennedy, J., Duffy, M. J., Crown, J. & O'Donovan, N., Dec 2012, In: Breast Cancer Research and Treatment. 136, 3, p. 717-727 11 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2011
RNAi knockdown of Hop (Hsp70/Hsp90 organising protein) decreases invasion via MMP-2 down regulation
Walsh, N., Larkin, A. M., Swan, N., Conlon, K., Dowling, P., McDermott, R. & Clynes, M., 28 Jul 2011, In: Cancer Letters. 306, 2, p. 180-189 10 p.Research output: Contribution to journal › Article › peer-review
Open Access80 Citations (Scopus) -
2010
Membrane transport proteins in human melanoma: Associations with tumour aggressiveness and metastasis
Walsh, N., Kennedy, S., Larkin, A. M., Tryfonopoulos, D., Eustace, A. J., Mahgoub, T., Conway, C., Oglesby, I., Collins, D., Ballot, J., Ooi, W. S., Gullo, G., Clynes, M., Crown, J. & O'Driscoll, L., Mar 2010, In: British Journal of Cancer. 102, 7, p. 1157-1162 6 p.Research output: Contribution to journal › Article › peer-review
Open Access34 Citations (Scopus) -
2009
Expression of multidrug resistance markers ABCB1 (MDR-1/P-gp) and ABCC1 (MRP-1) in renal cell carcinoma
Walsh, N., Larkin, A., Kennedy, S., Connolly, L., Ballot, J., Ooi, W., Gullo, G., Crown, J., Clynes, M. & O'Driscoll, L., 2009, In: BMC Urology. 9, 1, 6.Research output: Contribution to journal › Article › peer-review
Open Access80 Citations (Scopus) -
2007
A phase I clinical and pharmacokinetic study of the multi-drug resistance protein-1 (MRP-1) inhibitor sulindac, in combination with epirubicin in patients with advanced cancer
O'Connor, R., O'Leary, M., Ballot, J., Collins, C. D., Kinsella, P., Mager, D. E., Arnold, R. D., O'Driscoll, L., Larkin, A., Kennedy, S., Fennelly, D., Clynes, M. & Crown, J., Jan 2007, In: Cancer Chemotherapy and Pharmacology. 59, 1, p. 79-87 9 p.Research output: Contribution to journal › Article › peer-review
55 Citations (Scopus) -
MDR1/P-glycoprotein and MRP-1 drug efflux pumps in pancreatic carcinoma
O'Driscoll, L., Walsh, N., Larkin, A., Ballot, J., Ooi, W. S., Gullo, G., O'Connor, R., Clynes, M., Crown, J. & Kennedy, S., Jul 2007, In: Anticancer Research. 27, 4 B, p. 2115-2120 6 p.Research output: Contribution to journal › Article › peer-review
60 Citations (Scopus) -
MDR1/P-glycoprotein and MRP-1 mRNA and protein expression in non-small cell lung cancer
Roy, S., Kenny, E., Kennedy, S., Larkin, A., Ballot, J., Perez De Villarreal, M., Crown, J. & O'Driscoll, L., May 2007, In: Anticancer Research. 27, 3 A, p. 1325-1330 6 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
2006
MDR-1, but not MDR-3 gene expression, is associated with unmutated IgVH genes and poor prognosis chromosomal aberrations in chronic lymphocytic leukemia
Matthews, C., Catherwood, M. A., Larkin, A. M., Clynes, M., Morris, T. C. M. & Alexander, H. D., Nov 2006, In: Leukemia and Lymphoma. 47, 11, p. 2308-2313 6 p.Research output: Contribution to journal › Article › peer-review
47 Citations (Scopus) -
2005
Monoclonal antibody 5C3 raised against formalin fixed paraffin-embedded invasive breast tumour tissue: Characterisation of its reactive antigen via immunoprecipitation and internal sequencing
Larkin, A., Moran, E., Kennedy, S. M. & Clynes, M., Aug 2005, In: Journal of Immunological Methods. 303, 1-2, p. 53-65 13 p.Research output: Contribution to journal › Article › peer-review
6 Citations (Scopus) -
2004
Expression and Prognostic Relevance of Mcl-1 in Breast Cancer
O'Driscoll, L., Cronin, D., Kennedy, S. M., Purcell, R., Linehan, R., Glynn, S., Larkin, A., Scanlon, K., McDermott, E. W., Hill, A. D., O'Higgins, N. J., Parkinson, M. & Clynes, M., Mar 2004, In: Anticancer Research. 24, 2 A, p. 473-482 10 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Increased Anti-tumour Efficacy of Doxorubicin when Combined with Sulindac in a Xenograft Model of an MRP-1-positive Human Lung Cancer
O'Connor, R., Heenan, M., Connolly, L., Larkin, A. & Clynes, M., Mar 2004, In: Anticancer Research. 24, 2 A, p. 457-464 8 p.Research output: Contribution to journal › Article › peer-review
37 Citations (Scopus) -
Investigation of MRP-1 protein and MDR-1 P-glycoprotein expression in invasive breast cancer: A prognostic study
Larkin, A., O'Driscoll, L., Kennedy, S., Purcell, R., Moran, E., Crown, J., Parkinson, M. & Clynes, M., 1 Nov 2004, In: International Journal of Cancer. 112, 2, p. 286-294 9 p.Research output: Contribution to journal › Article › peer-review
Open Access83 Citations (Scopus) -
2002
Methods for generation of monoclonal antibodies to the very small drug hapten, 5-benzimidazolecarboxylic acid
Moran, E., O'Keeffe, M., O'Connor, R., Larkin, A. M., Murphy, P. & Clynes, M., 20 Dec 2002, In: Journal of Immunological Methods. 271, 1-2, p. 65-75 11 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2001
A new monoclonal antibody, P2A8(6), that specifically recognizes a novel epitope on the multidrug resistance-associated protein 1 (MRP1), but not on MRP2 nor MRP3
Connolly, L., Moran, E., Larkin, A., Scheffer, G., Scheper, R., Sarkadi, B., Kool, M. & Clynes, M., 2001, In: Hybridoma and Hybridomics. 20, 5-6, p. 333-341 9 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
2000
Low-dose twice-daily fractionates X-irradiation of ovarian tumor cells in vitro generates drug-resistant cells overexpressing two multidrug resistance-associated proteins, P-glycoprotein and MRP1
Hill, B. T., Moran, E., Etiévant, C., Perrin, D., Masterson, A., Larkin, A. & Whelan, R. D. H., 2000, In: Anti-Cancer Drugs. 11, 3, p. 193-200 8 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
1999
A new monoclonal antibody that specifically recognises the MDR-3- encoded gene product
Larkin, A., Moran, E., Alexander, D., Doherty, G., Connolly, L., Kennedy, S. M. & Clynes, M., 18 Jan 1999, In: International Journal of Cancer. 80, 2, p. 265-271 7 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Preliminary immunocytochemical studies of MDR-1 and MDR-3 Pgp expression in B-cell leukaemias
Larkin, A., Moran, E., Alexander, D. & Clynes, M., 1999, In: Advances in Experimental Medicine and Biology. 457, p. 65-70 6 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
1998
MDR1 expression is associated with adverse survival in melanoma of the uveal tract
Dunne, B. M., McNamara, M., Clynes, M., Shering, S. G., Larkin, A. M., Moran, E., Barnes, C. & Kennedy, S. M., 1998, In: Human Pathology. 29, 6, p. 594-598 5 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Monoclonal antibodies raised to paraffin wax embedded archival tissue; feasibility study of their potential to detect novel antigenic markers
Moran, E., Larkin, A., Cleary, I., Barnes, C., Kennedy, S. M., Kelehan, P. & Clynes, M., 1 Oct 1998, In: Journal of Immunological Methods. 219, 1-2, p. 151-159 9 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
1997
A new mdr-1 encoded P-170 specific monoclonal antibody: (6/1C) on paraffin wax embedded tissue without pretreatment of sections
Moran, E., Larkin, A., Doherty, G., Kelehan, P., Kennedy, S. & Clynes, M., 1997, In: Journal of Clinical Pathology. 50, 6, p. 465-471 7 p.Research output: Contribution to journal › Article › peer-review
Open Access20 Citations (Scopus) -
Co-expression of MDR-associated markers, including P-170, MRP and LRP and gytoskeletal proteins, in three resistant variants of the human ovarian garcinoma cell line, OAW42
Moran, E., Cleary, I., Larkin, A. M., Amhlaoibh, R. N., Masterson, A., Scheper, R. J., Izquierdo, M. A., Center, M., O'Sullivan, F. & Clynes, M., Apr 1997, In: European Journal of Cancer Part A. 33, 4, p. 652-660 9 p.Research output: Contribution to journal › Article › peer-review
31 Citations (Scopus)