Neville McClenaghan

2024

MicroRNA regulation of islet and enteroendocrine peptides: Physiology and therapeutic implications for type 2 diabetes

Carr, E. R., Higgins, P. B., McClenaghan, N. H., Flatt, P. R. & McCloskey, A. G., Jun 2024, In: Peptides. 176, 171196.

Research output: Contribution to journal › Article › peer-review

Open Access

Molecular determinants and intracellular targets of taurine signalling in pancreatic islet β-cells

Turbitt, J., Moffett, R. C., Brennan, L., Johnson, P. R. V., Flatt, P. R., McClenaghan, N. H. & Tarasov, A. I., Mar 2024, In: Acta Physiologica. 240, 3, e14101.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2023

NKCC transport mediates the insulinotropic effects of taurine and other small neutral amino acids

Turbitt, J., Brennan, L., Moffett, R. C., Flatt, P. R., Johnson, P. R. V., Tarasov, A. I. & McClenaghan, N. H., 1 Mar 2023, In: Life Sciences. 316, 121402.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Citations (Scopus)

Taurine rescues pancreatic β-cell stress by stimulating α-cell transdifferentiation

Sarnobat, D., Moffett, R. C., Ma, J., Flatt, P. R., McClenaghan, N. H. & Tarasov, A. I., 1 May 2023, In: BioFactors. 49, 3, p. 646-662 17 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

2019

Short-term CFTR inhibition reduces islet area in C57BL/6 mice

Khan, D., Kelsey, R., Maheshwari, R. R., Stone, V. M., Hasib, A., Manderson Koivula, F. N., Watson, A., Harkin, S., Irwin, N., Shaw, J. A., McClenaghan, N. H., Venglovecz, V., Ébert, A., Flodström-Tullberg, M., White, M. G. & Kelly, C., 1 Dec 2019, In: Scientific Reports. 9, 1, 11244.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

2016

Evaluation of the role of N-methyl-D-aspartate (NMDA) receptors in insulin secreting beta-cells

Patterson, S., Irwin, N., Guo-Parke, H., Moffett, R. C., Scullion, S. M., Flatt, P. R. & McClenaghan, N. H., 15 Jan 2016, In: European Journal of Pharmacology. 771, p. 107-113 7 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Improved antioxidative defence protects insulin-producing cells against homocysteine toxicity

Scullion, S. M., Hahn, C., Tyka, K., Flatt, P. R., McClenaghan, N. H., Lenzen, S. & Gurgul-Convey, E., 25 Aug 2016, In: Chemico-Biological Interactions. 256, p. 37-46 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

4 Citations (Scopus)

Molecular mechanisms of toxicity and cell damage by chemicals in a human pancreatic beta cell line, 1.1B4

Vasu, S., McClenaghan, N. H. & Flatt, P. R., 15 Sep 2016, In: Pancreas. 45, 9, p. 1320-1329 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

10 Citations (Scopus)

2015

Differential molecular and cellular responses of GLP-1 secreting L-cells and pancreatic alpha cells to glucotoxicity and lipotoxicity

Vasu, S., Charlotte Moffett, R., McClenaghan, N. H. & Flatt, P. R., 2015, In: Experimental Cell Research. 336, 1, p. 100-108 9 p.

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Pseudoislet formation enhances gene expression, insulin secretion and cytoprotective mechanisms of clonal human insulin-secreting 1.1B4 cells

Green, A. D., Vasu, S., McClenaghan, N. H. & Flatt, P. R., 13 Oct 2015, In: Pflugers Archiv European Journal of Physiology. 467, 10, p. 2219-2228 10 p.

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Responses of GLP1-secreting L-cells to cytotoxicity resemble pancreatic β-cells but not α-cells

Vasu, S., Charlotte Moffett, R., McClenaghan, N. H. & Flatt, P. R., 19 Dec 2015, In: Journal of Molecular Endocrinology. 54, 1, p. 91-104 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Citations (Scopus)

2014

Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4

Vasu, S., McClenaghan, N. H., McCluskey, J. T. & Flatt, P. R., 2014, In: Biochimica et Biophysica Acta - General Subjects. 1840, 1, p. 136-145 10 p.

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

2013

Cellular responses of novel human pancreatic β-cell line, 1.1B4 to hyperglycemia

Vasu, S., McClenaghan, N. H., McCluskey, J. T. & Flatt, P. R., Jul 2013, In: Islets. 5, 4, p. 170-177 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

Effects of lipotoxicity on a novel insulin-secreting human pancreatic β-cell line, 1.1B4

Vasu, S., McClenaghan, N. H., McCluskey, J. T. & Flatt, P. R., Jul 2013, In: Biological Chemistry. 394, 7, p. 909-918 10 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

2012

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

Guo-Parke, H., McCluskey, J. T., Kelly, C., Hamid, M., McClenaghan, N. H. & Flatt, P. R., Sep 2012, In: Journal of Endocrinology. 214, 3, p. 257-265 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

Enhancement of homocysteine toxicity to insulin-secreting BRIN-BD11 cells in combination with alloxan

Scullion, S. M. J., Gurgul-Convey, E., Elsner, M., Lenzen, S., Flatt, P. R. & McClenaghan, N. H., Aug 2012, In: Journal of Endocrinology. 214, 2, p. 233-238 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Citations (Scopus)

Physiological concentrations of interleukin-6 directly promote insulin secretion, signal transduction, nitric oxide release, and redox status in a clonal pancreatic β-cell line and mouse islets

Krause, M. D. S., Bittencourt, A., de Bittencourt, P. I. H., McClenaghan, N. H., Flatt, P. R., Murphy, C. & Newsholme, P., Sep 2012, In: Journal of Endocrinology. 214, 3, p. 301-311 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

41 Citations (Scopus)

2011

Acute and long-term effects of peroxisome proliferator-activated receptor-α activation on the function and insulin secretory responsiveness of clonal beta-cells

Irwin, N., McKinney, J. M., Bailey, C. J., McClenaghan, N. H. & Flatt, P. R., 2011, In: Hormone and Metabolic Research. 43, 4, p. 244-249 6 p.

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Development and functional characterization of insulin-releasing human pancreatic beta cell lines produced by electrofusion

McCluskey, J. T., Hamid, M., Guo-Parke, H., McClenaghan, N. H., Gomis, R. & Flatt, P. R., 24 Jun 2011, In: Journal of Biological Chemistry. 286, 25, p. 21982-21992 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

119 Citations (Scopus)

L-Arginine is essential for pancreatic β-cell functional integrity, metabolism and defense from inflammatory challenge

Krause, M. S., Mcclenaghan, N. H., Flatt, P. R., de Bittencourt, P. I. H., Murphy, C. & Newsholme, P., Oct 2011, In: Journal of Endocrinology. 211, 1, p. 87-97 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

72 Citations (Scopus)

2010

Acute and long-term effects of metformin on the function and insulin secretory responsiveness of clonal β-cells

McKiney, J. M., Irwin, N., Flatt, P. R., Bailey, C. J. & McClenaghan, N. H., Dec 2010, In: Biological Chemistry. 391, 12, p. 1451-1459 9 p.

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Cell-to-cell communication and cellular environment alter the somatostatin status of delta cells

Kelly, C., Flatt, P. R. & McClenaghan, N. H., 20 Aug 2010, In: Biochemical and Biophysical Research Communications. 399, 2, p. 162-166 5 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Comparison of insulin release from MIN6 pseudoislets and pancreatic islets of Langerhans reveals importance of homotypic cell interactions

Kelly, C., Guo, H., McCluskey, J. T., Flatt, P. R. & McClenaghan, N. H., Oct 2010, In: Pancreas. 39, 7, p. 1016-1023 8 p.

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Effects of metformin on BRIN-BD11 beta-cell insulin secretory desensitization induced by prolonged exposure to sulphonylureas

Irwin, N., McKinney, J. M., Bailey, C. J., Flatt, P. R. & McClenaghan, N. H., Dec 2010, In: Diabetes, Obesity and Metabolism. 12, 12, p. 1066-1071 6 p.

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

The role of glucagon-and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets

Kelly, C., Parke, H. G., McCluskey, J. T., Flatt, P. R. & McClenaghan, N. H., Oct 2010, In: Diabetes/Metabolism Research and Reviews. 26, 7, p. 525-533 9 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

2009

Overexpression of the malate-aspartate NADH shuttle member Aralar1 in the clonal β-cell line BRIN-BD11 enhances amino-acid-stimulated insulin secretion and cell metabolism

Bender, K., Maechler, P., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., 2009, In: Clinical Science. 117, 9, p. 321-330 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Prolonged L-alanine exposure induces changes in metabolism, Ca²⁺ handling and desensitization of insulin secretion in clonal pancreatic β-cells

McClenaghan, N. H., Scullion, S. M., Mion, B., Hewage, C., Malthouse, J. P. G., Flatt, P. R., Newsholme, P. & Brennan, L., Feb 2009, In: Clinical Science. 116, 4, p. 341-351 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Citations (Scopus)

Toll-like receptor agonist induced changes in clonal rat BRIN-BD11 β-cell insulin secretion and signal transduction

Kiely, A., Robinson, A., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Sep 2009, In: Journal of Endocrinology. 202, 3, p. 365-373 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

23 Citations (Scopus)

2007

Homocysteine-induced impairment of insulin secretion from clonal pancreatic BRIN-BD11 β-cells is not prevented by catalase

Patterson, S., Flatt, P. R. & McClenaghan, N. H., Jan 2007, In: Pancreas. 34, 1, p. 144-151 8 p.

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Major metabolic homocysteine-derivative, homocysteine thiolactone, exerts changes in pancreatic β-cell glucose-sensing, cellular signal transduction and integrity

Patterson, S., Flatt, P. R. & McClenaghan, N. H., 15 May 2007, In: Archives of Biochemistry and Biophysics. 461, 2, p. 287-293 7 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Physiological regulation of the pancreatic β-cell: Functional insights for understanding and therapy of diabetes

McClenaghan, N. H., May 2007, In: Experimental Physiology. 92, 3, p. 481-496 16 p.

Research output: Contribution to journal › Article › peer-review

Open Access

46 Citations (Scopus)

Pro-inflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic β-cell line

Kiely, A., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Oct 2007, In: Journal of Endocrinology. 195, 1, p. 113-123 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

57 Citations (Scopus)

Prolonged exposure to homocysteine results in diminished but reversible pancreatic β-cell responsiveness to insulinotropic agents

Patterson, S., Scullion, S. M. J., McCluskey, J. T., Flatt, P. R. & McClenaghan, N. H., May 2007, In: Diabetes/Metabolism Research and Reviews. 23, 4, p. 324-334 11 p.

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

2006

Actions of glucagon-like peptide-1 on K_ATP channel-dependent and -independent effects of glucose, sulphonylureas and nateglinide

McClenaghan, N. H., Flatt, P. R. & Ball, A. J., Sep 2006, In: Journal of Endocrinology. 190, 3, p. 889-896 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Citations (Scopus)

A stable analogue of glucose-dependent insulinotropic polypeptide, GIP(LysPAL¹⁶), enhances functional differentiation of mouse embryonic stem cells into cells expressing islet-specific genes and hormones

Marenah, L., McCluskey, J. T., Abdel-Wahab, Y. H. A., O'Harte, F. P. M., McClenaghan, N. H. & Flatt, P. R., 1 Jul 2006, In: Biological Chemistry. 387, 7, p. 941-947 7 p.

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Deleterious effects of supplementation with dehydroepiandrosterone sulphate or dexamethasone on rat insulin-secreting cells under in vitro culture condition

Liu, H. K., Green, B. D., McClenaghan, N. H., McCluskey, J. T. & Flatt, P. R., Feb 2006, In: Bioscience Reports. 26, 1, p. 31-38 8 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Detrimental actions of metabolic syndrome risk factor, homocysteine, on pancreatic β-cell glucose metabolism and insulin secretion

Patterson, S., Flatt, P. R., Brennan, L., Newsholme, P. & McClenaghan, N. H., May 2006, In: Journal of Endocrinology. 189, 2, p. 301-310 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

53 Citations (Scopus)

Glutamine regulates expression of key transcription factor, signal transduction, metabolic gene, and protein expression in a clonal pancreatic β-cell line

Corless, M., Kiely, A., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Sep 2006, In: Journal of Endocrinology. 190, 3, p. 719-727 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

51 Citations (Scopus)

Homocysteine and other structurally-diverse amino thiols can alter pancreatic beta cell function without evoking cellular damage

Patterson, S., Flatt, P. R. & McClenaghan, N. H., Jul 2006, In: Biochimica et Biophysica Acta - General Subjects. 1760, 7, p. 1109-1114 6 p.

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Investigation of the effects of sulfonylurea exposure on pancreatic beta cell metabolism

Brennan, L., Hewage, C., Malthouse, J. P. G., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Nov 2006, In: FEBS Journal. 273, 22, p. 5160-5168 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Citations (Scopus)

2005

Alterations of insulin secretion following long-term manipulation of ATP-sensitive potassium channels by diazoxide and nateglinide

Ball, A. J., Flatt, P. R. & McClenaghan, N. H., 1 Jan 2005, In: Biochemical Pharmacology. 69, 1, p. 59-63 5 p.

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Function of a long-term, GLP-1-treated, insulin-secreting cell line is improved by preventing DPP IV-mediated degradation of GLP-1

Green, B. D., Liu, H. K., McCluskey, J. T., Duffy, N. A., O'Harte, F. P. M., McClenaghan, N. H. & Flatt, P. R., Sep 2005, In: Diabetes, Obesity and Metabolism. 7, 5, p. 563-569 7 p.

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

L-alanine induces changes in metabolic and signal transduction gene expression in a clonal rat pancreatic β-cell line and protects from pro-inflammatory cytokine-induced apoptosis

Cunningham, G. A., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Nov 2005, In: Clinical Science. 109, 5, p. 447-455 9 p.

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

2004

Acute and long-term effects of nateglinide on insulin secretory pathways

Ball, A. J., Flatt, P. R. & McClenaghan, N. H., May 2004, In: British Journal of Pharmacology. 142, 2, p. 367-373 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

13 Citations (Scopus)

Arachidonic acid, palmitic acid and glucose are important for the modulation of clonal pancreatic β-cell insulin secretion, growth and functional integrity

Dixon, G., Nolan, J., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Feb 2004, In: Clinical Science. 106, 2, p. 191-199 9 p.

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Chronic exposure to tolbutamide and glibenclamide impairs insulin secretion but not transcription of K_ATP channel components

Ball, A. J., McCluskey, J. T., Flatt, P. R. & McClenaghan, N. H., Jul 2004, In: Pharmacological Research. 50, 1, p. 41-46 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Citations (Scopus)

Effects of Long-Term Exposure to Nicotinamide and Sodium Butyrate on Growth, Viability, and the Function of Clonal Insulin Secreting Cells

Liu, H. K., Green, B. D., Flatt, P. R., McClenaghan, N. H. & McCluskey, J. T., 2004, In: Endocrine Research. 30, 1, p. 61-68 8 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

Long-Term Beneficial Effects of Vanadate, Tungstate, and Molybdate on Insulin Secretion and Function of Cultured Beta Cells

Liu, H. K., Green, B. D., McClenaghan, N. H., McCluskey, J. T. & Flatt, P. R., May 2004, In: Pancreas. 28, 4, p. 364-368 5 p.

Research output: Contribution to journal › Article › peer-review

17 Citations (Scopus)

N-acetyl-GLP-1: A DPP IV-resistant analogue of glucagon-like peptide-1 (GLP-1) with improved effects on pancreatic β-cell-associated gene expression

Liu, H. K., Green, B. D., Gault, V. A., McCluskey, J. T., McClenaghan, N. H., O'Harte, F. P. M. & Flatt, P. R., Jan 2004, In: Cell Biology International. 28, 1, p. 69-73 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Citations (Scopus)

2003

¹³C NMR analysis reveals a link between L-glutamine metabolism, D-glucose metabolism and γ-glutamyl cycle activity in a clonal pancreatic beta-cell line

Brennan, L., Corless, M., Hewage, C., Malthouse, J. P. G., McClenaghan, N. H., Flatt, P. R. & Newsholme, P., Nov 2003, In: Diabetologia. 46, 11, p. 1512-1521 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

60 Citations (Scopus)

Neville McClenaghan

Research output

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