@inproceedings{6c56fefe6b364f19a564c5a76597b613,
title = "A folic acid labelled carbon quantum dot-protoporphryin IX conjugate for use in folate receptor targeted two-photon excited photodynamic therapy",
abstract = "Folic acid (FA) has been used as a molecular targeting strategy to improve the specificity of a CQD-protoporphyrin IX (CQD-PPIX) conjugate to folate receptor positive (FR+) HeLa cells for use in two-photon excited Photodynamic Therapy (TPE-PDT). FA was covalently attached to the CQD-PPIX conjugate to form a FA-CQD-PPIX conjugate. The uptake of the FA-CQD-PPIX conjugate in FR+ HeLa cells was shown to be 7 times greater than the CQD-PPIX conjugate, while both conjugates showed a similar uptake in FR negative (FR-) HT-47 cells. TPE-PDT experiments, using HeLa cells as a target, revealed a 30% improved cytotoxicity for cells treated with the FA-CQD-PPIX conjugate and TPE compared to controls treated with the CQD-PPIX conjugate and TPE. Collectively, these results suggest the presence of FA can facilitate targeting of CQD-sensitiser conjugates to FR+ cells resulting in an improved PDT effect.",
keywords = "Carbon Qunatum Dot, Folic Acid, PDT, Protoporphyrin IX",
author = "Dean Nicholas and Colin Fowley and McHale, {Anthony P.} and Sukanta Kamila and Jason Sheng and Jordan Atchison and Callan, {John F.}",
note = "Publisher Copyright: {\textcopyright} 2015 SPIE.; Colloidal Nanoparticles for Biomedical Applications X ; Conference date: 07-02-2015 Through 09-02-2015",
year = "2015",
doi = "10.1117/12.2084821",
language = "English",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Parak, {Wolfgang J.} and Marek Osinski and Xing-Jie Liang",
booktitle = "Colloidal Nanoparticles for Biomedical Applications X",
}