A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta

John Paul Cassella, Patrick J. Barrie, Norma Garrington, S. Yousuf Ali

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.

Original languageEnglish
Pages (from-to)291-296
Number of pages6
JournalJournal of Bone and Mineral Metabolism
Volume18
Issue number5
DOIs
Publication statusPublished - 2000
Externally publishedYes

Keywords

  • Composition
  • FTIR
  • Mineral
  • Osteogenesis imperfecta
  • P-NMR

Fingerprint

Dive into the research topics of 'A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta'. Together they form a unique fingerprint.

Cite this