A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta

John Paul Cassella; Patrick J. Barrie; Norma Garrington; S. Yousuf Ali

doi:10.1007/PL00010645

A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta

John Paul Cassella
, Patrick J. Barrie
, Norma Garrington
, S. Yousuf Ali

University of Derby
University College London
De Montfort University

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Fourier transform infrared spectroscopy and ³¹P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.

Original language	English
Pages (from-to)	291-296
Number of pages	6
Journal	Journal of Bone and Mineral Metabolism
Volume	18
Issue number	5
DOIs	https://doi.org/10.1007/PL00010645
Publication status	Published - 2000
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Composition
FTIR
Mineral
Osteogenesis imperfecta
P-NMR

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10.1007/PL00010645

Cite this

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title = "A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta",

abstract = "Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.",

keywords = "Composition, FTIR, Mineral, Osteogenesis imperfecta, P-NMR",

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year = "2000",

doi = "10.1007/PL00010645",

language = "English",

volume = "18",

pages = "291--296",

journal = "Journal of Bone and Mineral Metabolism",

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T1 - A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta

AU - Cassella, John Paul

AU - Barrie, Patrick J.

AU - Garrington, Norma

AU - Ali, S. Yousuf

PY - 2000

Y1 - 2000

N2 - Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.

AB - Fourier transform infrared spectroscopy and 31P solid-state nuclear magnetic resonance spectroscopy were used to determine if any structural or compositional differences in osteogenesis imperfecta (OI) bone mineral could be detected that might help to explain the bone fragility observed in this disease. A previous study by Cassella et al. used an electron probe X-ray microanalytical technique to compare the calcium to phosphorus (Ca/P) molar ratios in normal bone and bone from patients with OI. It was demonstrated that bone from OI patients had a lower Ca/P molar ratio. This study demonstrated that OI bone mineral had a general hydroxyapatite structure and that isomorphous substitutions in the carbanoapatite lattice could account for the low Ca/P molar ratio.

KW - Composition

KW - FTIR

KW - Mineral

KW - Osteogenesis imperfecta

KW - P-NMR

UR - https://www.scopus.com/pages/publications/0033821928

U2 - 10.1007/PL00010645

DO - 10.1007/PL00010645

M3 - Article

C2 - 10959620

AN - SCOPUS:0033821928

SN - 0914-8779

VL - 18

SP - 291

EP - 296

JO - Journal of Bone and Mineral Metabolism

JF - Journal of Bone and Mineral Metabolism

IS - 5

ER -

A Fourier transform infrared spectroscopic and solid-state NMR study of bone mineral in osteogenesis imperfecta

Abstract

UN SDGs

Keywords

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