TY - GEN
T1 - A low-cost, disposable GO-CS screen printed carbon electrode for electrochemical detection of tyrosine
AU - Dervin, Saoirse
AU - Ejaz, Ammara
AU - Dahiya, Ravinder
N1 - Publisher Copyright:
© 2020 IEEE.
PY - 2020/8/16
Y1 - 2020/8/16
N2 - A low-cost, sustainable and sensitive method for the continuous detection and quantification of Tyrosine (Tyr), a valuable metabolic biomarker, in biological fluids would present a valuable platform to aid patients and medical personnel in dietary management and the diagnosis and monitoring of metabolic and neurodegenerative disease. This work, therefore, presents a facile approach for the development of a graphene oxide (GO)-chitosan (CS) screen-printed carbon electrode (SPCE) (GO-CS/SPCE) on a flexible polyvinyl chloride (PVC) substrate, for the electrochemical detection of Tyr. The low-cost, disposable sensor was achieved by successfully immobilizing a homogenous GO-CS film at the surface of the SPCE via a simple ultrasound-assisted chemical reaction strategy. GO-CS was chosen as the sensitive nanocomposite film due to excellent electrochemical sensing properties, as well as the cost-effective, disposable and biocompatible nature of these nanomaterials. The GO-CS/SPCE demonstrated a wide linear range of 30-500 μM with a sensitivity of 0.03 μ Aμ M-1 and good reproducibility, highlighting the potential of GO-CS/SPCE as a low-cost, disposable and practical sensor for Tyr point of care (POC) testing.
AB - A low-cost, sustainable and sensitive method for the continuous detection and quantification of Tyrosine (Tyr), a valuable metabolic biomarker, in biological fluids would present a valuable platform to aid patients and medical personnel in dietary management and the diagnosis and monitoring of metabolic and neurodegenerative disease. This work, therefore, presents a facile approach for the development of a graphene oxide (GO)-chitosan (CS) screen-printed carbon electrode (SPCE) (GO-CS/SPCE) on a flexible polyvinyl chloride (PVC) substrate, for the electrochemical detection of Tyr. The low-cost, disposable sensor was achieved by successfully immobilizing a homogenous GO-CS film at the surface of the SPCE via a simple ultrasound-assisted chemical reaction strategy. GO-CS was chosen as the sensitive nanocomposite film due to excellent electrochemical sensing properties, as well as the cost-effective, disposable and biocompatible nature of these nanomaterials. The GO-CS/SPCE demonstrated a wide linear range of 30-500 μM with a sensitivity of 0.03 μ Aμ M-1 and good reproducibility, highlighting the potential of GO-CS/SPCE as a low-cost, disposable and practical sensor for Tyr point of care (POC) testing.
KW - Chitosan
KW - Graphene oxide
KW - PVC
KW - Point-of-care testing
KW - Screen-printed electrode
KW - Tyrosine
KW - disposable sensor
UR - http://www.scopus.com/inward/record.url?scp=85099529799&partnerID=8YFLogxK
U2 - 10.1109/FLEPS49123.2020.9239514
DO - 10.1109/FLEPS49123.2020.9239514
M3 - Conference contribution
AN - SCOPUS:85099529799
T3 - FLEPS 2020 - IEEE International Conference on Flexible and Printable Sensors and Systems
BT - FLEPS 2020 - IEEE International Conference on Flexible and Printable Sensors and Systems
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2020 IEEE International Conference on Flexible and Printable Sensors and Systems, FLEPS 2020
Y2 - 16 August 2020 through 19 August 2020
ER -