Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley; Anthony P. McHale; Bridgeen McCaughan; Aurore Fraix; Salvatore Sortino; John F. Callan

doi:10.1039/c4cc07827f

Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley, Anthony P. McHale, Bridgeen McCaughan, Aurore Fraix, Salvatore Sortino, John F. Callan

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	1
DOIs	https://doi.org/10.1039/c4cc07827f
Publication status	Published - 4 Jan 2015
Externally published	Yes

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10.1039/c4cc07827f

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abstract = "We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.",

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AU - Fraix, Aurore

AU - Sortino, Salvatore

AU - Callan, John F.

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N2 - We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

AB - We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

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Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Abstract

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