Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley; Anthony P. McHale; Bridgeen McCaughan; Aurore Fraix; Salvatore Sortino; John F. Callan

doi:10.1039/c4cc07827f

Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Colin Fowley
, Anthony P. McHale
, Bridgeen McCaughan
, Aurore Fraix
, Salvatore Sortino
, John F. Callan

Ulster University
University of Catania

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

Original language	English
Pages (from-to)	81-84
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	1
DOIs	https://doi.org/10.1039/c4cc07827f
Publication status	Published - 4 Jan 2015
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c4cc07827f

Cite this

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abstract = "We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.",

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AU - Fowley, Colin

AU - McHale, Anthony P.

AU - McCaughan, Bridgeen

AU - Fraix, Aurore

AU - Sortino, Salvatore

AU - Callan, John F.

PY - 2015/1/4

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N2 - We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

AB - We report a conjugate between carbon quantum dots and a NO photoreleaser able to photogenerate the anticancer NO radical via an energy transfer mechanism. This nanohybrid proved toxic to cancer cells in vitro and significantly reduced tumor volume in mice bearing human xenograft BxPC-3 pancreatic tumors upon two-photon excitation with the highly biocompatible 800 nm light.

UR - https://www.scopus.com/pages/publications/84915819826

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DO - 10.1039/c4cc07827f

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EP - 84

JO - Chemical Communications

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ER -

Carbon quantum dot-NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

Abstract

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