Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs

Bridgeen McCaughan; Claire Rouanet; Colin Fowley; Nikolitsa Nomikou; Anthony P. McHale; Paul A. McCarron; John F. Callan

doi:10.1016/j.bmcl.2011.08.015

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs

Bridgeen McCaughan, Claire Rouanet, Colin Fowley, Nikolitsa Nomikou, Anthony P. McHale, Paul A. McCarron, John F. Callan

Ulster University

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

Original language	English
Pages (from-to)	5750-5752
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	21
Issue number	19
DOIs	https://doi.org/10.1016/j.bmcl.2011.08.015
Publication status	Published - 1 Oct 2011
Externally published	Yes

Keywords

Light
Methylene blue
Photosensitiser
Ultrasound

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10.1016/j.bmcl.2011.08.015

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title = "Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs",

abstract = "A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.",

keywords = "Light, Methylene blue, Photosensitiser, Ultrasound",

author = "Bridgeen McCaughan and Claire Rouanet and Colin Fowley and Nikolitsa Nomikou and McHale, \{Anthony P.\} and McCarron, \{Paul A.\} and Callan, \{John F.\}",

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AU - McCaughan, Bridgeen

AU - Rouanet, Claire

AU - Fowley, Colin

AU - Nomikou, Nikolitsa

AU - McHale, Anthony P.

AU - McCarron, Paul A.

AU - Callan, John F.

PY - 2011/10/1

Y1 - 2011/10/1

N2 - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

AB - A combination of light and ultrasound activation of two conventional photosensitising drugs, methylene blue and rose bengal, was shown to generate higher levels of reactive oxygen species (ROS) and lower LD50 values than either light or ultrasound activation alone.

KW - Light

KW - Methylene blue

KW - Photosensitiser

KW - Ultrasound

UR - https://www.scopus.com/pages/publications/80052607654

U2 - 10.1016/j.bmcl.2011.08.015

DO - 10.1016/j.bmcl.2011.08.015

M3 - Article

C2 - 21875807

AN - SCOPUS:80052607654

SN - 0960-894X

VL - 21

SP - 5750

EP - 5752

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 19

ER -

Enhanced ROS production and cell death through combined photo- and sono-activation of conventional photosensitising drugs

Abstract

Keywords

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