TY - JOUR
T1 - Exploring Excipients
T2 - Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods
AU - Coyle, Robert
AU - Farrell, Garrett
AU - McFadden, Kim
AU - Warren, Patricia
N1 - Publisher Copyright:
©
PY - 2021/8/10
Y1 - 2021/8/10
N2 - This practical is aimed at students who have been introduced to the tableting process, drug delivery systems, and dissolution. The student can design and manufacture a tablet investigating the effect of excipients and their role in tablet design and then generate a release profile of the tablet by using a dissolution apparatus, flow-through cell, and UV-vis kinetics. Economical alternatives to the otherwise expensive dies, presses, and dissolution apparatus required to conduct the practical are included so that this can be applied across a range of budgets. With the assumption that most undergraduate laboratories possess a 13 mm KBr die and hydraulic press, a 10 mm die and 6 mm die can cost in excess of €850, while homemade versions can be manufactured for less than €5.
AB - This practical is aimed at students who have been introduced to the tableting process, drug delivery systems, and dissolution. The student can design and manufacture a tablet investigating the effect of excipients and their role in tablet design and then generate a release profile of the tablet by using a dissolution apparatus, flow-through cell, and UV-vis kinetics. Economical alternatives to the otherwise expensive dies, presses, and dissolution apparatus required to conduct the practical are included so that this can be applied across a range of budgets. With the assumption that most undergraduate laboratories possess a 13 mm KBr die and hydraulic press, a 10 mm die and 6 mm die can cost in excess of €850, while homemade versions can be manufactured for less than €5.
KW - Analytical Chemistry
KW - Applications of Chemistry
KW - Drugs/Pharmaceuticals
KW - Hands-On Learning/Manipulatives
KW - Interdisciplinary/Multidisciplinary
KW - Laboratory Instruction
KW - UV-Vis Spectroscopy
KW - Upper-Division Undergraduate
UR - http://www.scopus.com/inward/record.url?scp=85111541486&partnerID=8YFLogxK
U2 - 10.1021/acs.jchemed.1c00233
DO - 10.1021/acs.jchemed.1c00233
M3 - Article
AN - SCOPUS:85111541486
SN - 0021-9584
VL - 98
SP - 2687
EP - 2692
JO - Journal of Chemical Education
JF - Journal of Chemical Education
IS - 8
ER -