Exploring Excipients: Enhancing Solubility in Modified Drug Release Systems Using Inexpensive Tableting and Dissolution Methods

Robert Coyle, Garrett Farrell, Kim McFadden, Patricia Warren

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

This practical is aimed at students who have been introduced to the tableting process, drug delivery systems, and dissolution. The student can design and manufacture a tablet investigating the effect of excipients and their role in tablet design and then generate a release profile of the tablet by using a dissolution apparatus, flow-through cell, and UV-vis kinetics. Economical alternatives to the otherwise expensive dies, presses, and dissolution apparatus required to conduct the practical are included so that this can be applied across a range of budgets. With the assumption that most undergraduate laboratories possess a 13 mm KBr die and hydraulic press, a 10 mm die and 6 mm die can cost in excess of €850, while homemade versions can be manufactured for less than €5.

Original languageEnglish
Pages (from-to)2687-2692
Number of pages6
JournalJournal of Chemical Education
Volume98
Issue number8
DOIs
Publication statusPublished - 10 Aug 2021

Keywords

  • Analytical Chemistry
  • Applications of Chemistry
  • Drugs/Pharmaceuticals
  • Hands-On Learning/Manipulatives
  • Interdisciplinary/Multidisciplinary
  • Laboratory Instruction
  • UV-Vis Spectroscopy
  • Upper-Division Undergraduate

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