@inbook{1ab1d87aa4e14c148894bace7e870777,
title = "Finite Element and Animal Studies of Scar Contractions Leading to Chronic Wounds",
abstract = "Abnormally healing or chronic wounds can result in excessive scar contraction. While beneficial in reducing the overall size of the wound, excessive scar contraction has numerous negative side-effects. It can deform the surrounding skin; inhibit motion where contraction occurs near joints; cause tissue necrosis and induce pain. This study presents an experimental and finite element model of scar contraction. The constitutive model of skin is represented by a validated orthotropic-viscoelastic law. The finite element model successfully simulated key characteristics observed in the experiment, in particular, the size and pattern of wrinkles that formed around the contracting scar. The orthotropic nature of skin significantly influences the orientation of the wrinkles – they form in a direction perpendicular to the Langer lines in skin. The size of the wrinkles is limited by the pre-stress inherent in skin. The wrinkle range decreased 67% and the wrinkle length decreased 83% when the skin tension was increased from 2.9 to 12.1 Nm-1. Also, a non-linear constitutive law better simulates the behavior of skin than a linear law. The proposed model will be useful in designing strategies to improve the healing of chronic wounds. These strategies would include the application of appropriate mechanical forces in the region of a wound to promote healing, minimize scarring and improve the quality of life of the patient.",
keywords = "Biaxial Tension, Chronic Wound, Skin Model, Skin Sample, Vacuum Pressure",
author = "Cormac Flynn and Brendan McCormack",
note = "Publisher Copyright: {\textcopyright} 2009, Springer Berlin Heidelberg.",
year = "2009",
doi = "10.1007/978-3-642-00534-3_9",
language = "English",
series = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
publisher = "Springer",
pages = "207--233",
booktitle = "Studies in Mechanobiology, Tissue Engineering and Biomaterials",
}