Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide

Ciara Buckley; Emma J. Murphy; Therese R. Montgomery; Ian Major

doi:10.3390/polym14173442

Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide

Ciara Buckley
, Emma J. Murphy
, Therese R. Montgomery
, Ian Major

Technological University of the Shannon (TUS)

Research output: Contribution to journal › Review article › peer-review

136 Citations (Scopus)

Abstract

The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.

Original language	English
Article number	3442
Journal	Polymers
Volume	14
Issue number	17
DOIs	https://doi.org/10.3390/polym14173442
Publication status	Published - Sept 2022

Keywords

bioactives
drug-delivery
heteropolysaccharides
immunotherapies
naturally-occurring polymers
polysaccharide

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10.3390/polym14173442

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title = "Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide",

abstract = "The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.",

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author = "Ciara Buckley and Murphy, \{Emma J.\} and Montgomery, \{Therese R.\} and Ian Major",

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AU - Murphy, Emma J.

AU - Montgomery, Therese R.

AU - Major, Ian

PY - 2022/9

Y1 - 2022/9

N2 - The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.

AB - The inclusion of physiologically active molecules into a naturally occurring polymer matrix can improve the degradation, absorption, and release profile of the drug, thus boosting the therapeutic impact and potentially even reducing the frequency of administration. The human body produces significant amounts of polysaccharide hyaluronic acid, which boasts exceptional biocompatibility, biodegradability, and one-of-a-kind physicochemical features. In this review, we will examine the clinical trials currently utilizing hyaluronic acid and address the bright future of this versatile polymer, as well as summarize the numerous applications of hyaluronic acid in drug delivery and immunomodulation.

KW - bioactives

KW - drug-delivery

KW - heteropolysaccharides

KW - immunotherapies

KW - naturally-occurring polymers

KW - polysaccharide

UR - https://www.scopus.com/pages/publications/85137782919

U2 - 10.3390/polym14173442

DO - 10.3390/polym14173442

M3 - Review article

AN - SCOPUS:85137782919

SN - 2073-4360

VL - 14

JO - Polymers

JF - Polymers

IS - 17

M1 - 3442

ER -

Hyaluronic Acid: A Review of the Drug Delivery Capabilities of This Naturally Occurring Polysaccharide

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Keywords

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