TY - JOUR
T1 - Insulin-like growth factor-I is inversely related to adiposity in overweight Latino children
AU - Toledo-Corral, Claudia M.
AU - Roberts, Christian K.
AU - Shaibi, Gabriel Q.
AU - Lane, Christianne J.
AU - Higgins, Paul B.
AU - Davis, Jaimie N.
AU - Weigensberg, Marc J.
AU - Goran, Michael I.
PY - 2008/9
Y1 - 2008/9
N2 - The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
AB - The purpose of this study was to examine interrelationships between IGF-I, IGF binding proteins (IGFBPs) and adiposity in 178 overweight Hispanic adolescents (11.2 ± 1.7 yr; body mass index: 28.2 ± 5.4 kg/m2). Immunoradiometric assays were used to measure IGF-I, IGFBP-1 and IGFBP-3. Total fat and lean tissue mass were measured by DEXA and visceral and subcutaneous adipose tissue by MRI. IGF-I and IGFBP-3 remained inversely correlated with total body fat mass (r = -0.52, p <0.001 and r = -0.25, p <0.01, respectively) after controlling for covariates. IGFBP-1 was inversely correlated to total fat mass (r = -0.55, p <0.001) in simple correlations; however, this relationship was eliminated after controlling for covariates (r = 0.02, p = 0.85). Correlations with visceral and subcutaneous adipose tissue yielded similar results. These results demonstrate that IGF-I, IGFBP-1 and IGFBP-3 are all inversely related to adiposity in Hispanic children.
KW - Children
KW - IGF
KW - IGFBP-1
KW - IGFBP-3
KW - Obesity
KW - Visceral fat
UR - http://www.scopus.com/inward/record.url?scp=53849124323&partnerID=8YFLogxK
U2 - 10.1515/JPEM.2008.21.9.855
DO - 10.1515/JPEM.2008.21.9.855
M3 - Article
C2 - 18924579
AN - SCOPUS:53849124323
SN - 0334-018X
VL - 21
SP - 855
EP - 864
JO - Journal of Pediatric Endocrinology and Metabolism
JF - Journal of Pediatric Endocrinology and Metabolism
IS - 9
ER -
