Mechanisms of toxicity by proinflammatory cytokines in a novel human pancreatic beta cell line, 1.1B4

Biochemistry, Genetics and Molecular Biology

• Cytokine 100%
• Proinflammatory Cytokine 100%
• Transcription 42%
• Glucokinase 28%
• Nitrosative Stress 28%
• Protein Expression 28%
• Oxidative Stress 28%
• Messenger RNA 14%
• DNA 14%
• Caspase 3 14%
• Caspase 14%
• Interleukin-1 14%
• Alanine 14%
• Comet Assay 14%
• STAT1 14%
• GJA1 14%
• Cell Damage 14%
• NFKB1 14%
• Insulin Release 14%
• Enzyme Activity 14%
• DNA Fragmentation 14%
• Transcription Factor PDX 1 14%
• Quantitative Reverse Transcription Polymerase Chain Reaction 14%
• SOD2 14%
• MTT Assay 14%
• GPX1 14%
• Western Blot 14%
• Upregulation 14%
• Tumor Necrosis Factor 14%

Immunology and Microbiology

• 1.1B4 Cell Line 100%
• Cytokine 100%
• Proinflammatory Cytokine 100%
• Oxidative Stress 28%
• Caspase 28%
• Protein Expression 28%
• Nitrosative Stress 28%
• Comet Assay 14%
• STAT1 14%
• Radioimmunoassay 14%
• Western Blot 14%
• Tumor Necrosis Factor 14%
• Cell Line 14%
• DNA Fragmentation 14%
• Enzyme Activity 14%
• Insulin Release 14%
• Upregulation 14%
• Cell Damage 14%
• Quantitative Reverse Transcription Polymerase Chain Reaction 14%
• Interleukin-1 14%
• Transcription Factor PDX 1 14%

Pharmacology, Toxicology and Pharmaceutical Science

• Cytokine 100%
• Nitrite 22%
• Glucokinase 22%
• Calcium Ion 22%
• Western Blot 11%
• Caspase 11%
• Caspase 3 11%
• Alanine 11%
• Glucagon-Like Peptide-1 11%
• Messenger RNA 11%
• Radioimmunoassay 11%
• Comet Assay 11%
• Forskolin 11%
• Tumor Necrosis Factor 11%
• Antioxidant 11%
• GPX1 11%
• Transcription Factor PDX 1 11%