Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou; Colin Fowley; Niall M. Byrne; Bridgeen McCaughan; Anthony P. McHale; John F. Callan

doi:10.1039/c2cc33913g

Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy

Nikolitsa Nomikou, Colin Fowley, Niall M. Byrne, Bridgeen McCaughan, Anthony P. McHale, John F. Callan

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

Original language	English
Pages (from-to)	8332-8334
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	67
DOIs	https://doi.org/10.1039/c2cc33913g
Publication status	Published - 25 Jul 2012
Externally published	Yes

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10.1039/c2cc33913g

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title = "Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy",

abstract = "A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.",

author = "Nikolitsa Nomikou and Colin Fowley and Byrne, {Niall M.} and Bridgeen McCaughan and McHale, {Anthony P.} and Callan, {John F.}",

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AU - Nomikou, Nikolitsa

AU - Fowley, Colin

AU - Byrne, Niall M.

AU - McCaughan, Bridgeen

AU - McHale, Anthony P.

AU - Callan, John F.

PY - 2012/7/25

Y1 - 2012/7/25

N2 - A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

AB - A Rose Bengal sonosensitiser has been covalently attached to a lipid microbubble and the resulting conjugate shown to produce higher levels of singlet oxygen, enhanced cytotoxicity in a cancer cell line and a greater reduction in tumour growth than the sonosensitiser alone.

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U2 - 10.1039/c2cc33913g

DO - 10.1039/c2cc33913g

M3 - Article

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SN - 1359-7345

VL - 48

SP - 8332

EP - 8334

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

Microbubble–sonosensitiser conjugates as therapeutics in sonodynamic therapy

Abstract

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