Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Jordan Atchison; Sukanta Kamila; Conor McEwan; Heather Nesbitt; James Davis; Colin Fowley; Bridgeen Callan; Anthony P. McHale; John F. Callan

doi:10.1039/c5cc07022h

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Jordan Atchison, Sukanta Kamila, Conor McEwan, Heather Nesbitt, James Davis, Colin Fowley, Bridgeen Callan, Anthony P. McHale, John F. Callan

Ulster University

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

Original language	English
Pages (from-to)	16832-16835
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	94
DOIs	https://doi.org/10.1039/c5cc07022h
Publication status	Published - 30 Sep 2015
Externally published	Yes

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10.1039/c5cc07022h

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abstract = "A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.",

author = "Jordan Atchison and Sukanta Kamila and Conor McEwan and Heather Nesbitt and James Davis and Colin Fowley and Bridgeen Callan and McHale, {Anthony P.} and Callan, {John F.}",

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AU - Atchison, Jordan

AU - Kamila, Sukanta

AU - McEwan, Conor

AU - Nesbitt, Heather

AU - Davis, James

AU - Fowley, Colin

AU - Callan, Bridgeen

AU - McHale, Anthony P.

AU - Callan, John F.

PY - 2015/9/30

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AB - A new sensitiser (4) for use in photodynamic therapy (PDT) has been developed to enable control of ROS production as a function of pH. This pH dependent PDT behaviour was tested in HeLa cells and in SCID mice bearing human xenograft pancreatic cancer (BxPC-3) tumours.

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EP - 16835

JO - Chemical Communications

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ER -

Modulation of ROS production in photodynamic therapy using a pH controlled photoinduced electron transfer (PET) based sensitiser

Abstract

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