Whole blood thallium determination by GFAAS with high-frequency modulation polarization Zeeman effect background correction

Nikolay D. Solovyev, Natalya B. Ivanenko, Anatoly A. Ivanenko

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A new technique of blood thallium direct determination based on graphite furnace atomic absorption spectrometry with Zeeman background absorption correction system was designed. The developed technique does not require sample digestion. Sample treatment includes only a fivefold per volume dilution of blood sample with 0.1% (m/v) Triton X-100. L'vov integrated platform was modified with 400 μg of Rh. Matrix modifier (200 μg NH4NO 3 and 160 μg Pd(NO3)2) was suggested for coping chloride and blood organic matter interferences. Standard reference material (Clincheck® Plasma Control for trace elements) analysis was used for validation. Additional validation was performed by analyzing spiked blood samples in the whole dynamic range. The dynamic range was 2-50 μg/L. Precision (RSD) was found <12%. Blood thallium limit of detection was 0.2 μg/L.

Original languageEnglish
Pages (from-to)591-599
Number of pages9
JournalBiological Trace Element Research
Volume143
Issue number1
DOIs
Publication statusPublished - Oct 2011
Externally publishedYes

Keywords

  • Blood analysis
  • Graphite furnace atomic absorption spectrometry
  • Modifiers in GFAAS
  • Thallium
  • Trace element

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