TY - JOUR
T1 - Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit
AU - the VIP1 study group
AU - Guidet, Bertrand
AU - Flaatten, Hans
AU - Boumendil, Ariane
AU - Morandi, Alessandro
AU - Andersen, Finn H.
AU - Artigas, Antonio
AU - Bertolini, Guido
AU - Cecconi, Maurizio
AU - Christensen, Steffen
AU - Faraldi, Loredana
AU - Fjølner, Jesper
AU - Jung, Christian
AU - Marsh, Brian
AU - Moreno, Rui
AU - Oeyen, Sandra
AU - Öhman, Christina Agwald
AU - Pinto, Bernardo Bollen
AU - Soliman, Ivo W.
AU - Szczeklik, Wojciech
AU - Valentin, Andreas
AU - Watson, Ximena
AU - Zafeiridis, Tilemachos
AU - De Lange, Dylan W.
AU - Schmutz, René
AU - Wimmer, Franz
AU - Eller, Philipp
AU - Zotter, Klemens
AU - De Buysscher, Pieter
AU - De Neve, Nikolaas
AU - Swinnen, Walter
AU - Abraham, Paul
AU - Hergafi, Leila
AU - Schefold, Joerg C.
AU - Biskup, Ewelina
AU - Taliadoros, Ioannis
AU - Piza, Petr
AU - Lauten, Alexander
AU - Sacher, Anna Lena
AU - Brenner, Thorsten
AU - Franz, Marcus
AU - Bloos, Frank
AU - Ebelt, Henning
AU - Schaller, Stefan J.
AU - Fuest, Kristina
AU - Rabe, Christian
AU - Dieck, Thorben
AU - Steiner, Stephan
AU - Graf, Tobias
AU - Nia, Amir M.
AU - Faulkner, Maria
N1 - Publisher Copyright:
© 2018, Springer-Verlag GmbH Germany, part of Springer Nature and ESICM.
PY - 2018/7/1
Y1 - 2018/7/1
N2 - Purpose: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. Methods: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. Results: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU length of stay. The ICU and 30-day mortality were, respectively, 29.1 and 53.1% in the withholding group and 82.2% and 93.1% in the withdrawal group. LST was less frequently limited in eastern and southern European countries than in northern Europe. The patient-independent factors associated with LST limitation were: acute ICU admission (OR 5.77, 95% CI 4.32–7.7), Clinical Frailty Scale (CFS) score (OR 2.08, 95% CI 1.78–2.42), increased age (each 5 years of increase in age had a OR of 1.22 (95% CI 1.12–1.34) and SOFA score [OR of 1.07 (95% CI 1.05–1.09 per point)]. The frequency of LST limitation was higher in countries with high GDP and was lower in religious countries. Conclusions: The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country. Trial registration: ClinicalTrials.gov (ID: NTC03134807).
AB - Purpose: To document and analyse the decision to withhold or withdraw life-sustaining treatment (LST) in a population of very old patients admitted to the ICU. Methods: This prospective study included intensive care patients aged ≥ 80 years in 309 ICUs from 21 European countries with 30-day mortality follow-up. Results: LST limitation was identified in 1356/5021 (27.2%) of patients: 15% had a withholding decision and 12.2% a withdrawal decision (including those with a previous withholding decision). Patients with LST limitation were older, more frail, more severely ill and less frequently electively admitted. Patients with withdrawal of LST were more frequently male and had a longer ICU length of stay. The ICU and 30-day mortality were, respectively, 29.1 and 53.1% in the withholding group and 82.2% and 93.1% in the withdrawal group. LST was less frequently limited in eastern and southern European countries than in northern Europe. The patient-independent factors associated with LST limitation were: acute ICU admission (OR 5.77, 95% CI 4.32–7.7), Clinical Frailty Scale (CFS) score (OR 2.08, 95% CI 1.78–2.42), increased age (each 5 years of increase in age had a OR of 1.22 (95% CI 1.12–1.34) and SOFA score [OR of 1.07 (95% CI 1.05–1.09 per point)]. The frequency of LST limitation was higher in countries with high GDP and was lower in religious countries. Conclusions: The most important patient variables associated with the instigation of LST limitation were acute admission, frailty, age, admission SOFA score and country. Trial registration: ClinicalTrials.gov (ID: NTC03134807).
KW - Elderly
KW - Ethics
KW - Intensive care
KW - Life sustaining treatment
KW - Withdrawal
KW - Withholding
UR - http://www.scopus.com/inward/record.url?scp=85047108358&partnerID=8YFLogxK
U2 - 10.1007/s00134-018-5196-7
DO - 10.1007/s00134-018-5196-7
M3 - Article
C2 - 29774388
AN - SCOPUS:85047108358
SN - 0342-4642
VL - 44
SP - 1027
EP - 1038
JO - Intensive Care Medicine
JF - Intensive Care Medicine
IS - 7
ER -